BAR+

Sequence already in BAR+ !

Cluster:	Cluster identification, Annotations (GO,PDB,Pfam), Cluster HMM (when possible)
Query:	Your input, Alignment to template/s (when possible)
SI:	Pairwise Sequence Identity
COV:	Overlapping of the pairwise alignment as defined in the Help
BLAST Match:	Sequences that match your query, UniProt code (if available) or other description
cov:	Overlapping of the PDB template over the query (if available)
id:	PDB template/query sequence identity (if available)
-	-
GREEN:	Identical sequences
RED:	SI ≥ 40% and COV ≥ 90%
GREY:	SI < 40% and COV < 90%

Cluster	Query	SI	COV	BLAST Match
Cluster-ID: 331 No. sequences: 2172 Average length: 347.7 (10.2% SD) Eukaryota 2172 Gene Ontology function (Total: 150) Molecular Function: (Validated:3/8) MHC class I receptor activity peptide antigen binding antigen binding Biological Process: (Validated:72/128) positive regulation of tolerance induction to nonself antigen alpha-beta T cell activation involved in immune response regulation of T cell mediated immunity induction of apoptosis regulation of natural killer cell mediated immunity negative regulation of natural killer cell mediated immunity positive regulation of T cell mediated immunity positive regulation of natural killer cell mediated immunity T cell activation involved in immune response antigen processing and presentation of exogenous peptide antigen via MHC class I T cell mediated immunity positive regulation of lymphocyte mediated immunity induction of programmed cell death positive regulation of apoptosis regulation of apoptosis negative regulation of lymphocyte mediated immunity antigen processing and presentation of endogenous peptide antigen via MHC class Ib protection from natural killer cell mediated cytotoxicity antigen processing and presentation of exogenous peptide antigen via MHC class Ib positive regulation of nitric oxide biosynthetic process regulation of nitric oxide biosynthetic process natural killer cell mediated immunity lymphocyte activation involved in immune response antigen processing and presentation of peptide antigen via MHC class I positive regulation of T cell mediated cytotoxicity regulation of T cell mediated cytotoxicity antigen processing and presentation of exogenous peptide antigen regulation of leukocyte mediated immunity positive regulation of leukocyte mediated immunity positive regulation of adaptive immune response lymphocyte mediated immunity positive regulation of programmed cell death regulation of programmed cell death defense response to bacterium negative regulation of natural killer cell mediated cytotoxicity negative regulation of innate immune response negative regulation of leukocyte mediated immunity positive regulation of natural killer cell mediated cytotoxicity positive regulation of interferon-gamma production regulation of tolerance induction dependent upon immune response positive regulation of tolerance induction dependent upon immune response regulation of natural killer cell mediated cytotoxicity regulation of interferon-gamma production negative regulation of defense response antigen processing and presentation of peptide antigen regulation of leukocyte mediated cytotoxicity T cell mediated cytotoxicity positive regulation of leukocyte mediated cytotoxicity antigen processing and presentation of exogenous antigen adaptive immune response leukocyte mediated immunity response to bacterium negative regulation of leukocyte mediated cytotoxicity positive regulation of immune effector process tolerance induction dependent upon immune response antigen processing and presentation of endogenous antigen positive regulation of immune response T cell tolerance induction positive regulation of tolerance induction antigen processing and presentation leukocyte mediated cytotoxicity positive regulation of cell killing positive regulation of immune system process positive regulation of response to stimulus positive regulation of cellular process negative regulation of immune system process negative regulation of response to stimulus negative regulation of cell killing response to other organism multi-organism process positive regulation of biological process cell killing Cellular Component: (Validated:5/14) integral to membrane external side of plasma membrane protein complex cell surface macromolecular complex Structural annotation (No. PDB: 33) 3bzfP 1m05A 2bckA 1a6zA 1zt1A 1e27A 3bevA 1kjmA 1nezA 3kynA 2dypA 1k8dA 1mhcA 1a9eA 1x7qA 1ogaA 2fwoA 1a1mA 2hjlA 1biiA 1im9A 1efxA 3bzeP 3bo8A 1xr9A 1m6oA 3bzfA 1hsbA 2bvpA 1k5nA 1s7qA 1s7uA 1ldpH Ligands: GOL URE CL NDG ALA SO4 ARG SCOP: d.19.1.1 # b.1.1.2 Pfam annotation (Total: 1) No validated Pfam for this cluster Cluster HMM Download HMM Download cluster annotation data	P30459 3bzfP 3-10 (start-end) 2.2% cov \| 90.0% id PIR alignment 1biiA 1-365 (start-end) 99.2% cov \| 70.0% id PIR alignment	100.0	100.0	P30459 Taxonomy: Eukaryota Organism: Homo sapiens (Human) Description: HLA class I histocompatibility antigen, A-74 alpha chain